IgG Suppresses Antibody Responses to Sheep Pink Blood Cells in Double Knock-Out Mice Missing Complement Issue C3 and Activating Fcγ-Receptors
Complement C5 however not C3 is expendable for tissue issue activation by cofactor-independent antiphospholipid antibodies.
In Vitro and In Vivo Variations in Murine Third Complement Part (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms.
Useful and structural characterization of 4 mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic purposes.
C3 is the central element of the complement system. Upon activation, C3 sequentially generates numerous proteolytic fragments, C3a, C3b, iC3b, C3dg, every of them exposing novel surfaces, that are websites of interplay with different proteins. C3 and its fragments are therapeutic targets and markers of complement activation.
We report the structural and useful characterization of 4 monoclonal antibodies (mAbs) generated by immunizing C3-deficient mice with a combination of human C3b, iC3b and C3dg fragments, and focus on their potential purposes. This assortment contains three mAbs interacting with native C3 and inhibiting AP complement activation; two of them by blocking the cleavage of C3 by the AP C3-converase and one by impeding formation of the AP C3-convertase.
complement C3 (C3) Antibody |
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abx432532-200ul | Abbexa | 200 ul | EUR 343.2 |
C3 Antibody / Complement C3 |
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RQ6122 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. |
C3 Antibody / Complement C3 |
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RQ4854 | NSJ Bioreagents | 100ul | EUR 356.15 |
Description: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [UniProt] |
Complement C3 antibody |
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10-1813 | Fitzgerald | 200 ul | EUR 651.6 |
Description: Mouse monoclonal Complement C3 antibody |
Complement C3 antibody |
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10R-2963 | Fitzgerald | 100 ug | EUR 318 |
Description: Mouse monoclonal C3 antibody |
Complement C3 antibody |
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10R-7446 | Fitzgerald | 100 ul | EUR 471.6 |
Description: Mouse monoclonal Complement C3 antibody |
Complement C3 antibody |
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10R-7447 | Fitzgerald | 100 ul | EUR 471.6 |
Description: Mouse monoclonal Complement C3 antibody |
Complement C3 antibody |
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20-S0503GND1-D0 | Fitzgerald | 10 ml | EUR 165.6 |
Description: Goat polyclonal Human Complement C3 antibody |
Complement C3 antibody |
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20-S0511G000-S4 | Fitzgerald | 1 ml | EUR 159.6 |
Description: Goat polyclonal Complement C3 antibody |
Complement C3 antibody |
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20-S0511G000-V0 | Fitzgerald | 10 ml | EUR 159.6 |
Description: Goat polyclonal Human Complement C3 antibody |
Complement C3 antibody |
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20-S5060GOOO-S4 | Fitzgerald | 10 ml | EUR 139.2 |
Description: Goat polyclonal Human Complement C3 antibody |
Complement C3 antibody |
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88R-7581 | Fitzgerald | 1 ml | EUR 198 |
Description: Goat polyclonal Complement C3 antiserum |
Complement C3 antibody |
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70R-10688 | Fitzgerald | 1 ml | EUR 417.6 |
Description: Rabbit polyclonal Complement C3 antibody |
Complement C3 antibody |
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70R-12569 | Fitzgerald | 100 ul | EUR 548.4 |
Description: Affinity purified Rabbit polyclonal Complement C3 antibody |
Complement C3 antibody |
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20-1010 | Fitzgerald | 1 liter | Ask for price |
Description: Goat polyclonal Complement C3 antibody (Nephelometric and Turbidimetric grade) |
Complement C3 antibody |
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20-1730 | Fitzgerald | 1 L | Ask for price |
Description: Sheep Anti-Human C3c - IgG Faction |
Complement C3 antibody |
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20-CG80 | Fitzgerald | 1 L | Ask for price |
Description: Goat polyclonal Complement C3 antibody |
Complement C3 antibody |
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20-CG80S | Fitzgerald | 1 L | Ask for price |
Description: Goat polyclonal Complement C3 antibody |
Complement 3 (C3) Antibody |
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abx024152-50ml | Abbexa | 50 ml | EUR 727.2 |
Complement C3 antibody (FITC) |
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60-S0504GA01-AF | Fitzgerald | 5 ml | EUR 204 |
Description: Goat polyclonal Human Complement C3 antibody (FITC) |
Human Complement C3 Antibody |
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11221-05011 | AssayPro | 150 ug | EUR 260.4 |
Human Complement C3 Antibody |
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41221-05011 | AssayPro | 150 ug | EUR 260.4 |
Complement C3 Convertase (C3) Antibody |
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20-abx270259 | Abbexa |
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Complement C3 Convertase (C3) Antibody |
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20-abx102334 | Abbexa |
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Complement C3 Convertase (C3) Antibody |
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20-abx129535 | Abbexa |
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Complement C3 (C3C) Antibody |
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abx224425-100ug | Abbexa | 100 ug | EUR 493.2 |
Complement C3 (C3C) Antibody |
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abx224309-100ug | Abbexa | 100 ug | EUR 493.2 |
Complement C3 Beta Chain (C3) Antibody |
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abx019059-100ug | Abbexa | 100 ug | EUR 410.4 |
The interplay websites of those mAbs within the goal molecules had been decided by resolving the constructions of Fab fragments sure to C3b and/or iC3b utilizing electron microscopy. A fourth mAb particularly acknowledges the iC3b, C3dg, and C3d fragments. It binds to an evolutionary-conserved neoepitope generated after C3b cleavage by FI, detecting iC3b/C3dg deposition over opsonized surfaces by movement cytometry and immunohistochemistry in human and different species.