IgG Suppresses Antibody Responses to Sheep Pink Blood Cells in Double Knock-Out Mice Missing Complement Issue C3 and Activating Fcγ-Receptors
Complement C5 however not C3 is expendable for tissue issue activation by cofactor-independent antiphospholipid antibodies.
In Vitro and In Vivo Variations in Murine Third Complement Part (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms.
Useful and structural characterization of 4 mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic purposes.
C3 is the central element of the complement system. Upon activation, C3 sequentially generates numerous proteolytic fragments, C3a, C3b, iC3b, C3dg, every of them exposing novel surfaces, that are websites of interplay with different proteins. C3 and its fragments are therapeutic targets and markers of complement activation.
We report the structural and useful characterization of 4 monoclonal antibodies (mAbs) generated by immunizing C3-deficient mice with a combination of human C3b, iC3b and C3dg fragments, and focus on their potential purposes. This assortment contains three mAbs interacting with native C3 and inhibiting AP complement activation; two of them by blocking the cleavage of C3 by the AP C3-converase and one by impeding formation of the AP C3-convertase.
complement C3 (C3) Antibody |
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abx432532-200ul | Abbexa | 200 ul | EUR 343.2 |
C3 Antibody / Complement C3 |
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RQ4854 | NSJ Bioreagents | 100ul | EUR 419 |
C3 Antibody / Complement C3 |
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RQ6122 | NSJ Bioreagents | 100 ug | EUR 419 |
Description: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. |
Chicken Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Ch-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Chicken Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Ch-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Human Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Hu-48T | DL Develop | 48T | EUR 451.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Human Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Hu-96T | DL Develop | 96T | EUR 576 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Mouse Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Mu-48T | DL Develop | 48T | EUR 586.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Mouse Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Mu-96T | DL Develop | 96T | EUR 762 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Porcine Complement Component 3 (C3) ELISA Kit |
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DLR-C3-p-48T | DL Develop | 48T | EUR 656.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Porcine Complement Component 3 (C3) ELISA Kit |
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DLR-C3-p-96T | DL Develop | 96T | EUR 858 |
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Complement Component 3 (C3) in samples from serum, plasma or other biological fluids. |
Rat Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Ra-48T | DL Develop | 48T | EUR 609.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Complement Component 3 (C3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Complement Component 3 (C3) ELISA Kit |
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DLR-C3-Ra-96T | DL Develop | 96T | EUR 793.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Complement Component 3 (C3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Chicken Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Ch-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Chicken Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Ch-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Human Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 453.6 |
Human Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 622.8 |
Mouse Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Porcine Complement Component 3 (C3) ELISA Kit |
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RDR-C3-p-48Tests | Reddot Biotech | 48 Tests | EUR 696 |
Porcine Complement Component 3 (C3) ELISA Kit |
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RDR-C3-p-96Tests | Reddot Biotech | 96 Tests | EUR 968.4 |
Rat Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Complement Component 3 (C3) ELISA Kit |
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RDR-C3-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Chicken Complement Component 3 (C3) ELISA Kit |
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RD-C3-Ch-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Chicken Complement Component 3 (C3) ELISA Kit |
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RD-C3-Ch-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Human Complement Component 3 (C3) ELISA Kit |
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RD-C3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 434.4 |
Human Complement Component 3 (C3) ELISA Kit |
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RD-C3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 595.2 |
Mouse Complement Component 3 (C3) ELISA Kit |
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RD-C3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 586.8 |
The interplay websites of those mAbs within the goal molecules had been decided by resolving the constructions of Fab fragments sure to C3b and/or iC3b utilizing electron microscopy. A fourth mAb particularly acknowledges the iC3b, C3dg, and C3d fragments. It binds to an evolutionary-conserved neoepitope generated after C3b cleavage by FI, detecting iC3b/C3dg deposition over opsonized surfaces by movement cytometry and immunohistochemistry in human and different species.